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TGIF1 Antibody

CAT: 0223-56-207Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-207Size:400 µL
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Background
The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and eight variants, encoding four distinct isoforms, are described.
NCBI Gene ID
7050
Swiss Prot
Q15583
Accession Number
Q15583
Host
Rabbit
Reactivity
Human
Immunogen
This TGIF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 145-174 amino acids from the Central region of human TGIF1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Neuroscience, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Chicken
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
43 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
TGIF1
NCBI Official Name
Homeobox protein TGIF1
NCBI Organism
Homo sapiens
Background Reference 01
Bengoechea-Alonso, M.T., et al. Oncogene 29 (38) :5322-5328 (2010)
Background Reference 02
Paulussen, A.D., et al. Eur. J. Hum. Genet. 18 (9) :999-1005 (2010)
Background Reference 03
Jugessur, A., et al. PLoS ONE (7), E11493 (2010) :
Background Reference 04
Demange, C., et al. Mol. Cell 36 (6) :1073-1085 (2009)
Other Product Names
Homeobox protein TGIF1, 5'-TG-3'-interacting factor 1, TGIF1, TGIF
Tested Applications
WB
Protein ID
215274200
Physical Properties
Liquid

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