IRF9 Antibody

• Background:

  IRF9 is a transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta) . Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

• NCBI Gene ID:

  10379

• Swiss Prot:

  Q00978

• Accession Number:

  Q00978

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  This IRF9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-104 amino acids from the N-terminal region of human IRF9.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Inflammasomes

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  44 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  IRF9

• NCBI Official Name:

  Interferon regulatory factor 9

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Maiwald, T., et al. FEBS J. 277 (22) :4741-4754 (2010)

• Background Reference 02:

  Schuurhof, A., et al. Pediatr. Pulmonol. 45 (6) :608-613 (2010)

• Background Reference 03:

  Watanabe, T., et al. J. Clin. Invest. 120 (5) :1645-1662 (2010)

• Background Reference 04:

  Mosbruger, T.L., et al. J. Infect. Dis. 201 (9) :1371-1380 (2010)

• Other Product Names:

  Interferon regulatory factor 9, IRF-9, IFN-alpha-responsive transcription factor subunit, ISGF3 p48 subunit, Interferon-stimulated gene factor 3 gamma, ISGF-3 gamma, Transcriptional regulator ISGF3 subunit gamma, IRF9, ISGF3G

• Tested Applications:

  WB, IHC-P, IF

• Protein ID:

  266392

• Physical Properties:

  Liquid