IRF1 Antibody

• Background:

  IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion.

• NCBI Gene ID:

  3659

• Swiss Prot:

  P10914

• Accession Number:

  P10914

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This IRF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 260-286 amino acids from the C-terminal region of human IRF1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other, Inflammasomes

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  37 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  IRF1

• NCBI Official Name:

  Interferon regulatory factor 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Silva, L.K., et al. Eur. J. Hum. Genet. 18 (11) :1221-1227 (2010)

• Background Reference 02:

  Matsuzaki, S., et al. J. Immunol. 185 (8) :4863-4872 (2010)

• Background Reference 03:

  Antonios, D., et al. J. Immunol. 185 (1) :89-98 (2010)

• Background Reference 04:

  Lou, Y.J., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27 (3) :255-258 (2010)

• Other Product Names:

  Interferon regulatory factor 1, IRF-1, IRF1

• Tested Applications:

  WB

• Protein ID:

  20178295

• Physical Properties:

  Liquid