TRPM8 Antibody

CAT: 0223-56-033Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-56-033Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
NCBI Gene ID
79054
Swiss Prot
Q7Z2W7
Accession Number
Q7Z2W7
Host
Rabbit
Reactivity
Human
Immunogen
This TRPM8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-292 amino acids from the Central region of human TRPM8.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Neuroscience, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
128 kDa
Fragment
Rabbit Ig
Symbol
TRPM8
NCBI Official Name
Transient receptor potential cation channel subfamily M member 8
NCBI Organism
Homo sapiens
Background Reference 01
Yee, N.S., et al. Cancer Lett. 297 (1) :49-55 (2010) Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010) Kuhn, F.J., et al. J. Biol. Chem. 285 (35) :26806-26814 (2010) Gkika, D., et al. Oncogene 29 (32) :4611-4616 (2010) Van Haute, C., et al. ScientificWorldJournal 10, 1597-1611 (2010) :
Other Product Names
Transient receptor potential cation channel subfamily M member 8, Long transient receptor potential channel 6, LTrpC-6, LTrpC6, Transient receptor potential p8, Trp-p8, TRPM8, LTRPC6, TRPP8
Tested Applications
WB, IHC-P, IF
Protein ID
143811469
Physical Properties
Liquid

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