TRPM8 Antibody

• Background:

  Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.

• NCBI Gene ID:

  79054

• Swiss Prot:

  Q7Z2W7

• Accession Number:

  Q7Z2W7

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This TRPM8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-292 amino acids from the Central region of human TRPM8.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Neuroscience, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  128 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  TRPM8

• NCBI Official Name:

  Transient receptor potential cation channel subfamily M member 8

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Yee, N.S., et al. Cancer Lett. 297 (1) :49-55 (2010) Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010) Kuhn, F.J., et al. J. Biol. Chem. 285 (35) :26806-26814 (2010) Gkika, D., et al. Oncogene 29 (32) :4611-4616 (2010) Van Haute, C., et al. ScientificWorldJournal 10, 1597-1611 (2010) :

• Other Product Names:

  Transient receptor potential cation channel subfamily M member 8, Long transient receptor potential channel 6, LTrpC-6, LTrpC6, Transient receptor potential p8, Trp-p8, TRPM8, LTRPC6, TRPP8

• Tested Applications:

  WB, IHC-P, IF

• Protein ID:

  143811469

• Physical Properties:

  Liquid