TRPM4 Antibody

• Background:

  The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. Two transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  54795

• Swiss Prot:

  Q8TD43

• Accession Number:

  Q8TD43

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This TRPM4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1121-1149 amino acids from the C-terminal region of human TRPM4.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  134 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  TRPM4

• NCBI Official Name:

  Transient receptor potential cation channel subfamily M member 4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Liu, H., et al. Circ Cardiovasc Genet 3 (4) :374-385 (2010)

• Background Reference 02:

  Yoo, J.C., et al. Biochem. Biophys. Res. Commun. 391 (1) :806-811 (2010)

• Background Reference 03:

  Kruse, M., et al. J. Clin. Invest. 119 (9) :2737-2744 (2009)

• Background Reference 04:

  Marigo, V., et al. Mol. Cell. Endocrinol. 299 (2) :194-203 (2009)

• Other Product Names:

  Transient receptor potential cation channel subfamily M member 4, hTRPM4, Calcium-activated non-selective cation channel 1, Long transient receptor potential channel 4, LTrpC-4, LTrpC4, Melastatin-4, TRPM4, LTRPC4

• Tested Applications:

  WB

• Protein ID:

  74715868

• Physical Properties:

  Liquid