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TAF1 Antibody

CAT: 0223-56-031Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-031Size:400 µL
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Background
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. This gene is part of a complex transcriptional unit (TAF1/DYT3), wherein some products share exons with TAF1 as well as additional exons downstream.
NCBI Gene ID
6872
Swiss Prot
P21675
Accession Number
P21675
Host
Rabbit
Reactivity
Mouse
Immunogen
This TAF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1863-1893 amino acids from the C-terminal region of human TAF1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
213 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
TAF1
NCBI Official Name
Transcription initiation factor TFIID subunit 1
NCBI Organism
Homo sapiens
Background Reference 01
Tavassoli, P., et al. Mol. Endocrinol. 24 (4) :696-708 (2010)
Background Reference 02
Allende-Vega, N., et al. Mol. Cell. Biochem. 316 (1-2), 99-106 (2008) :
Background Reference 03
Centeno, F., et al. Intervirology 51 (2) :137-143 (2008)
Background Reference 04
Olejnik-Schmidt, A.K., et al. Arch. Virol. 153 (5) :983-990 (2008)
Other Product Names
Transcription initiation factor TFIID subunit 1, Cell cycle gene 1 protein, TBP-associated factor 250 kDa, p250, Transcription initiation factor TFIID 250 kDa subunit, TAF (II) 250, TAFII-250, TAFII250, TAF1, BA2R, CCG1, CCGS, TAF2A
Tested Applications
WB
Protein ID
115942
Physical Properties
Liquid

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