CREB1 Antibody

• Background:

  This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.

• NCBI Gene ID:

  1385

• Swiss Prot:

  P16220

• Accession Number:

  P16220

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  This CREB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 105-132 amino acids from the Central region of human CREB1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Immunology, Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  37 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CREB1

• NCBI Official Name:

  Cyclic AMP-responsive element-binding protein 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Jablonski, K.A., et al. Diabetes 59 (10) :2672-2681 (2010) Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010) Chen, G., et al. J. Neurosci. 30 (39) :13066-13077 (2010) Serretti, A., et al.Affect Disord (2010) In pressMelnikova, V.O., et al. PLoS ONE (8), E12452 (2010) :

• Other Product Names:

  Cyclic AMP-responsive element-binding protein 1, CREB-1, cAMP-responsive element-binding protein 1, CREB1

• Tested Applications:

  WB, IF, Flow

• Protein ID:

  117434

• Physical Properties:

  Liquid