CREB3 Antibody

• Background:

  This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.

• NCBI Gene ID:

  10488

• Swiss Prot:

  O43889

• Accession Number:

  O43889

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CREB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the N-terminal region of human CREB3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  44 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CREB3

• NCBI Official Name:

  Cyclic AMP-responsive element-binding protein 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kim, H.C., et al. Cell. Mol. Life Sci. 67 (20) :3499-3510 (2010)

• Background Reference 02:

  Eleveld-Trancikova, D., et al. Mol. Immunol. 47 (11-12), 1963-1973 (2010) :

• Background Reference 03:

  Kang, H., et al. Mol. Endocrinol. 23 (11) :1746-1757 (2009)

• Background Reference 04:

  Mamdani, F., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 147B (4), 500-504 (2008) :

• Other Product Names:

  Cyclic AMP-responsive element-binding protein 3, CREB-3, cAMP-responsive element-binding protein 3, Leucine zipper protein, Luman, Transcription factor LZIP-alpha, Processed cyclic AMP-responsive element-binding protein 3, N-terminal Luman, Transcriptionally active form, CREB3, LZIP

• Tested Applications:

  WB

• Physical Properties:

  Liquid