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CREB3 Antibody

CAT: 0223-60-832Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-832Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.
NCBI Gene ID
10488
Swiss Prot
O43889
Accession Number
O43889
Host
Rabbit
Reactivity
Human
Immunogen
This CREB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the N-terminal region of human CREB3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
44 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CREB3
NCBI Official Name
Cyclic AMP-responsive element-binding protein 3
NCBI Organism
Homo sapiens
Background Reference 01
Kim, H.C., et al. Cell. Mol. Life Sci. 67 (20) :3499-3510 (2010)
Background Reference 02
Eleveld-Trancikova, D., et al. Mol. Immunol. 47 (11-12), 1963-1973 (2010) :
Background Reference 03
Kang, H., et al. Mol. Endocrinol. 23 (11) :1746-1757 (2009)
Background Reference 04
Mamdani, F., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 147B (4), 500-504 (2008) :
Other Product Names
Cyclic AMP-responsive element-binding protein 3, CREB-3, cAMP-responsive element-binding protein 3, Leucine zipper protein, Luman, Transcription factor LZIP-alpha, Processed cyclic AMP-responsive element-binding protein 3, N-terminal Luman, Transcriptionally active form, CREB3, LZIP
Tested Applications
WB
Physical Properties
Liquid

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