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ISG15 Antibody

CAT: 0223-55-888Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-888Size:400 µL
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Background
ISG15 is secreted from monocytes in response to type I interferons and causes natural killer (NK) -cell proliferation and an augmentation of non-MCH (major histocompatibility complex) -restricted cytotoxicity. Synthesis is stimulated by IFN-alpha or IFN-beta or IFN-omega , but not IFN-gamma . ISG15 expression is also induced by overexpression of interferon regulatory factors that participate in transcriptional regulation of IFN genes, and by influenza B virus. ISG15 is secreted also by cell lines of monocyte, T-lymphocyte, B-lymphocyte, human fibroblasts, and epithelial origins. The induction of terminal differentiation in human melanoma cells is associated with alterations in ISG15 expression. Enhancement of NK cell proliferation, augmentation of non-major histocompatibility complex-restricted cytotoxicity, and induction of IFN-gamma from T cells identify ISG15 as a member of the cytokine cascade and suggest that it may be responsible for amplifying and directing some of the immunomodulatory effects of IFN-alpha or IFN-beta. ISG15 has has also been shown to function intracellularly as a ubiquitin homolog.
NCBI Gene ID
9636
Swiss Prot
P05161
Accession Number
P05161
Host
Rabbit
Reactivity
Human
Immunogen
This ISG15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 72-99 amino acids from the Central region of human ISG15.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
18 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
ISG15
NCBI Official Name
Ubiquitin-like protein ISG15
NCBI Organism
Homo sapiens
Background Reference 01
Padovan, E., et al., Cancer Res. 62 (12) :3453-3458 (2002) .
Background Reference 02
Meraro, D., et al., J. Immunol. 168 (12) :6224-6231 (2002) .
Background Reference 03
Reich, N., et al., Proc. Natl. Acad. Sci. U.S.A. 84 (18) :6394-6398 (1987) .
Background Reference 04
Blomstrom, D.C., et al., J. Biol. Chem. 261 (19) :8811-8816 (1986) .
Other Product Names
Ubiquitin-like protein ISG15, Interferon-induced 15 kDa protein, Interferon-induced 17 kDa protein, IP17, Ubiquitin cross-reactive protein, hUCRP, ISG15, G1P2, UCRP
Tested Applications
WB
Protein ID
52001470
Physical Properties
Liquid

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