COPE Antibody

• Background:

  The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.

• NCBI Gene ID:

  11316

• Swiss Prot:

  O14579

• Accession Number:

  O14579

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This COPE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-300 amino acids from the C-terminal region of human COPE.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Chicken, Hamster, Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  34 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  COPE

• NCBI Official Name:

  Coatomer subunit epsilon

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)

• Background Reference 02:

  Morikawa, R.K., et al. J. Biol. Chem. 284 (39) :26620-26630 (2009)

• Background Reference 03:

  Maruyama, S., et al. Mol. Cell. Biochem. 307 (1-2), 73-82 (2008) :

• Background Reference 04:

  Goryachev, A.B., et al. PLoS Comput. Biol. (12), E172 (2006) :

• Other Product Names:

  Coatomer subunit epsilon, Epsilon-coat protein, Epsilon-COP, COPE

• Tested Applications:

  WB, IHC-P, IF

• Physical Properties:

  Liquid