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NCOR1 Antibody

CAT: 0223-55-711Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-711Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NCOR1 mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. The gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined.
NCBI Gene ID
9611
Swiss Prot
O75376
Accession Number
O75376
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This NCOR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-47 amino acids from the N-terminal region of human NCOR1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
270 kDa
Fragment
Rabbit Ig
Symbol
NCOR1
NCBI Official Name
Nuclear receptor corepressor 1
NCBI Organism
Homo sapiens
Background Reference 01
Tai, H.H., et al., Biochem. Biophys. Res. Commun. 308 (1) :170-176 (2003) .
Background Reference 02
Ishizuka, T., et al., Mol. Cell. Biol. 23 (15) :5122-5131 (2003) .
Background Reference 03
Loinder, K., et al., J. Steroid Biochem. Mol. Biol. 84 (1) :15-21 (2003) .
Background Reference 04
Wang, S., et al., Oncogene 21 (55) :8388-8396 (2002) .
Other Product Names
Nuclear receptor corepressor 1, N-CoR, N-CoR1, NCOR1, KIAA1047
Tested Applications
WB, IHC-P, IF
Physical Properties
Liquid

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