NCOR1 Antibody

• Background:

  NCOR1 mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. The gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined.

• NCBI Gene ID:

  9611

• Swiss Prot:

  O75376

• Accession Number:

  O75376

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This NCOR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-47 amino acids from the N-terminal region of human NCOR1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  270 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  NCOR1

• NCBI Official Name:

  Nuclear receptor corepressor 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Tai, H.H., et al., Biochem. Biophys. Res. Commun. 308 (1) :170-176 (2003) .

• Background Reference 02:

  Ishizuka, T., et al., Mol. Cell. Biol. 23 (15) :5122-5131 (2003) .

• Background Reference 03:

  Loinder, K., et al., J. Steroid Biochem. Mol. Biol. 84 (1) :15-21 (2003) .

• Background Reference 04:

  Wang, S., et al., Oncogene 21 (55) :8388-8396 (2002) .

• Other Product Names:

  Nuclear receptor corepressor 1, N-CoR, N-CoR1, NCOR1, KIAA1047

• Tested Applications:

  WB, IHC-P, IF

• Physical Properties:

  Liquid