CYP2D6 Antibody

• Background:

  This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  1565

• Swiss Prot:

  P10635

• Accession Number:

  P10635

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CYP2D6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-105 amino acids from the N-terminal region of human CYP2D6.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  56 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CYP2D6

• NCBI Official Name:

  Cytochrome P450 2D6

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Abduljalil, K., et al. Clin. Pharmacol. Ther. 88 (5) :643-651 (2010)

• Background Reference 02:

  Novalbos, J., et al.Clin Psychopharmacol 30 (5) :504-511 (2010)

• Background Reference 03:

  Thompson, A.M., et al. Breast Cancer Res. Treat. (2010) In press :

• Background Reference 04:

  Gonzalez-Tejera, G., et al.R Health Sci29 (3) :299-304 (2010)

• Other Product Names:

  Cytochrome P450 2D6, CYPIID6, Cytochrome P450-DB1, Debrisoquine 4-hydroxylase, CYP2D6, CYP2DL1

• Tested Applications:

  WB, IHC-P

• Protein ID:

  84028191

• Physical Properties:

  Liquid