CYP2D6 Antibody

CAT: 0223-57-786Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-57-786Size:400 µL
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Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
1565
Swiss Prot
P10635
Accession Number
P10635
Host
Rabbit
Reactivity
Human
Immunogen
This CYP2D6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-105 amino acids from the N-terminal region of human CYP2D6.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
56 kDa
Fragment
Rabbit Ig
Symbol
CYP2D6
NCBI Official Name
Cytochrome P450 2D6
NCBI Organism
Homo sapiens
Background Reference 01
Abduljalil, K., et al. Clin. Pharmacol. Ther. 88 (5) :643-651 (2010)
Background Reference 02
Novalbos, J., et al.Clin Psychopharmacol 30 (5) :504-511 (2010)
Background Reference 03
Thompson, A.M., et al. Breast Cancer Res. Treat. (2010) In press :
Background Reference 04
Gonzalez-Tejera, G., et al.R Health Sci29 (3) :299-304 (2010)
Other Product Names
Cytochrome P450 2D6, CYPIID6, Cytochrome P450-DB1, Debrisoquine 4-hydroxylase, CYP2D6, CYP2DL1
Tested Applications
WB, IHC-P
Protein ID
84028191
Physical Properties
Liquid

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