MAPK Antibody

CAT: 0223-50-207Size: 0.1 mLDry Ice: NoHazardous: No
CAT#:0223-50-207Size:0.1 mL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Extracellular-Signal Regulated Kinase/Mitogen-Activated Protein Kinase (ERK/MAPK) is an integral component of cellular signaling during mitogenesis and differentiation of mitotic cells and also is thought to play a key role in learning and memory (Adams and Sweatt, 2002; Ahn, 1993; Tanoue and Nishida, 2003; Johnson and Lapadat, 2002) . The activity of this kinase is regulated by dual phosphorylation at Thr202 and Tyr204 (Ahn, 1993) .
NCBI Gene ID
116590
Swiss Prot
P63086
Accession Number
P63086
Host
Rabbit
Reactivity
Mouse, Rat
Immunogen
Peptide corresponding to amino acid residues from the C-terminus of rat ERK/MAPK.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
Affinity Purified
Concentration
Batch dependent
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
MAPK antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year.
Calculated Molecular Weight
42/44
Applications Notes
The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will also react with mouse tissue based on the fact that this species has 100% homology with the amino acid sequence used as antigen.
Symbol
Mapk1
NCBI Official Name
Mitogen activated protein kinase 1
NCBI Organism
Rattus norvegicus
Background Reference 01
Adams JP, Sweatt JD (2002) Molecular psychology: Roles for the ERK MAP kinase cascade in memory. Annu Rev Pharmacol Toxicol 42:135-163.
Background Reference 02
Ahn, NG (1993) The MAP kinase cascade. Discovery of a new signal transduction pathway. Mol Cell Biochem 127-128:201-209.
Background Reference 03
Johnson GL, Lapadat R (2002) Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298:1911-1912.
Tested Applications
WB
Protein ID
52001075
Physical Properties
Liquid

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