MAPK Antibody
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
MAPK Antibody
Background:
Extracellular-Signal Regulated Kinase/Mitogen-Activated Protein Kinase (ERK/MAPK) is an integral component of cellular signaling during mitogenesis and differentiation of mitotic cells and also is thought to play a key role in learning and memory (Adams and Sweatt, 2002; Ahn, 1993; Tanoue and Nishida, 2003; Johnson and Lapadat, 2002) . The activity of this kinase is regulated by dual phosphorylation at Thr202 and Tyr204 (Ahn, 1993) .NCBI Gene ID:
116590Swiss Prot:
P63086Accession Number:
P63086Host:
RabbitReactivity:
Mouse, RatImmunogen:
Peptide corresponding to amino acid residues from the C-terminus of rat ERK/MAPK.Clonality:
PolyclonalConjugation:
UnconjugatedType:
Primary AntibodiesField of Research:
Signal TransductionPurification:
Affinity PurifiedConcentration:
Batch dependentModification:
NoneShipping Conditions:
Blue IceStorage Conditions:
MAPK antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year.Calculated Molecular Weight:
42/44Applications Notes:
The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will also react with mouse tissue based on the fact that this species has 100% homology with the amino acid sequence used as antigen.Symbol:
Mapk1NCBI Official Name:
Mitogen activated protein kinase 1NCBI Organism:
Rattus norvegicusBackground Reference 01:
Adams JP, Sweatt JD (2002) Molecular psychology: Roles for the ERK MAP kinase cascade in memory. Annu Rev Pharmacol Toxicol 42:135-163.Background Reference 02:
Ahn, NG (1993) The MAP kinase cascade. Discovery of a new signal transduction pathway. Mol Cell Biochem 127-128:201-209.Background Reference 03:
Johnson GL, Lapadat R (2002) Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298:1911-1912.Tested Applications:
WBProtein ID:
52001075Physical Properties:
Liquid