P38 MAPK (Ab 182) Antibody

• Background:

  Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis.

• NCBI Gene ID:

  1432

• Swiss Prot:

  Q16539

• Accession Number:

  NP_001306.1

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  P38 MAPK (Ab-182) antibody was raised against a peptide sequence around aa. 180~184 (T-G-Y-V-A) derived from Human P38 MAPK.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  43 kDa

• Specificity:

  This antibody detects endogenous level of total P38MAPK protein.

• Applications Notes:

  Western Blot: 1:500~1:1000

• Symbol:

  MAPK14

• NCBI Official Name:

  Mitogen-activated protein kinase 14

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ming Zheng, et al. (2005) The FASEB Journal. 19: 109-111Bernt van den et al. (2001) Blink Immunology, 166: 582-587Arshad Rahman, et al. (2004) Am J Physiol Lung Cell Mol Physiol 287: L1017-L1024Osamu Yoshino, et al. (2003) Endocrinology & Metabolism Vol. 88: 2236-2241

• Other Product Names:

  RK, p38, CSBP, EXIP, Mxi2, CSBP1, CSBP2, CSPB1, PRKM14, PRKM15, SAPK2A, p38ALPHA, MAPK2, MAPKAPK-2, MAPKAPK2

• Tested Applications:

  WB

• Protein ID:

  4503069

• Physical Properties:

  Liquid