Synaptophysin Antibody

• Background:

  Synaptophysin 2, also known as synaptoporin, is a component of the synaptic vesicle membrane and thought to play an important role in synaptic vesicle trafficking (Dai et al., 2003) . It is highly homologous to synaptophysin 1, yet differs in expression. Whereas synaptophysin 1 is ubiquitiously expressed, synaptophysin 2 is concentrated in the mossy fiber synapses of the hippocampus (Grabs et al., 1994; Singec et al., 2002) .

• NCBI Gene ID:

  66030

• Swiss Prot:

  P22831

• Accession Number:

  P22831

• Host:

  Rabbit

• Reactivity:

  Mouse, Rat

• Immunogen:

  Peptide corresponding to amino acid residues from the C-terminal region of rat synaptophysin 2, conjugated to keyhole limpet hemocyanin (KLH) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  Affinity Purified

• Concentration:

  Batch dependent

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Synaptophysin antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year.

• Calculated Molecular Weight:

  38

• Symbol:

  Synpr

• NCBI Official Name:

  Synaptoporin

• NCBI Organism:

  Rattus norvegicus

• Background Reference 01:

  Dai J, Ji C, Gu S, Wu Q, Wang L, Xu J, Zeng L, Ye X, Yin G, Xie Y, Mao Y (2003) Cloning and sequence analysis of the human cDNA encoding the synaptoporin, a highly conserved synaptic vesicle protein. Molecular Biology Reports 30:185-191.

• Background Reference 02:

  Singec I, Knoth R, Ditter M, Hagemeyer CE, Rosenbrock H, Frotscher M, Volk B (2002) Synaptic vesicle protein synaptoporin is differently expressed by subpopulations of mouse hippocampal neurons. J Comp Neurol 452 (2) :139-153.

• Background Reference 03:

  Grabs D, Bergmann M, Schuster T, Fox PA, Brich M, Gratz M (1994) Differential expression of synaptophysin and synaptoporin during pre- and postnatal development of the rat hippocampal network. Eur J Neurosci. 6 (11) : 1765-71..

• Tested Applications:

  WB

• Protein ID:

  33112632

• Physical Properties:

  Liquid