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Synaptophysin 2 Antibody

CAT: 0223-79-661Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-661Size:0.1 mg
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Background
Synaptophysin (SYP) is a neuronal synaptic vesicle glycoprotein that is expressed in neuroendocrine cells and neoplasms, and thus can be used as a marker in tumor diagnosis (1) . Synaptophysin contains four transmembrane domains that form a hexameric channel or gap junction-like pore (2) . Synaptophysin binds to the SNARE protein synaptobrevin/VAMP, which prevents the inclusion of synaptobrevin in the synaptic vesicle fusion complex and creates a pool of synaptobrevin for exocytosis when synapse activity increases (3) . Synaptophysin is also responsible for targeting synaptobrevin 2/VAMP2 to synaptic vesicles, a critical component of the fusion complex (4) .
NCBI Gene ID
66030
Swiss Prot
P22831
Accession Number
NP_076464.1
Host
Rabbit
Reactivity
Rat
Immunogen
Synaptophysin 2 antibody was raised against a peptide sequence around aa.257~261 (G-P-T-S-F) derived from Rat synaptophysin 2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
37 kDa
Specificity
This antibody detects endogenous levels of total synaptophysin 2 protein.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
Synpr
NCBI Official Name
Synaptoporin
NCBI Organism
This antibody was raised against a peptide sequence around aa.257~261 (G-P-T-S-F) derived from Rat synaptophysin 2.
Background Reference 01
Wiedenmann, B. et al. (1986) Proc Natl Acad Sci USA 83, 3500-4. Valtorta, F. et al. (2004) Bioessays 26, 445-53. Arthur, C. P. and Stowell, M. H. (2007) Structure 15, 707-14. Bonanomi, D. et al. (2007) Biochem J 404, 525-34.
Other Product Names
Synpr
Tested Applications
WB
Protein ID
13027428
Physical Properties
Liquid

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