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14-3-3 Antibody

CAT: 0223-50-178Size: 0.1 mLDry Ice: NoHazardous: No
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CAT#:0223-50-178Size:0.1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
14-3-3 proteins are a family of highly conserved proteins that appear to have multiple roles in cell signaling (Bridges and Moorhead, 2005) . The proteins are abundantly expressed in the brain and have been detected in the cerebrospinal fluid of patients with different neurological disorders (Berg et al., 2003) . 14-3-3 proteins bind protein ligands that are typically phosphorylated on serine or threonine residues and regulate the functions of these binding partners by a number of different mechanisms (Silhan et al., 2004; Dougherty and Morrison, 2004) . The 14-3-3 proteins affect a diverse array of cellular processes including the cell cycle and transcription, signal transduction and intracellular trafficking.
NCBI Gene ID
56011
Swiss Prot
P35213
Accession Number
P35213
Host
Rabbit
Reactivity
Human, Mouse, Rat, Dog, Zebrafish, Bovine, Chicken, Frog
Immunogen
Peptide corresponding to amino acid residues from the C-terminal region of 14-3-3 protein, conjugated to keyhole limpet hemocyanin (KLH) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Affinity Purified
Concentration
Batch dependent
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
14-3-3 antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year.
Calculated Molecular Weight
29
Applications Notes
The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with bovine, canine, chicken, human, mouse, non-human primates, Xenopus and zebra fish based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
Symbol
Ywhab
NCBI Official Name
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
NCBI Organism
Rattus norvegicus
Background Reference 01
Berg D, Holzmann C, Riess O (2003) 14-3-3 Proteins in the nervous system. Nat Rev Neurosci 4:752-762.
Background Reference 02
Bridges D, Moorhead GB (2005) 14-3-3 Proteins: a number of functions for a numbered protein. Sci STKE 2005:re10.
Background Reference 03
Dougherty MK, Morrison DK (2004) Unlocking the code of 14-3-3. J Cell Sci 117:1875-1884.
Tested Applications
WB
Protein ID
1345591
Physical Properties
Liquid

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