PARL Antibody

• Background:

  PARL is a rhomboid protease which has been shown to be involved in mitochondrial remodeling. PARL has also been shown to have antiapoptotic activity and protects cells from mitochondrial-dependent apoptotic pathway.

• NCBI Gene ID:

  55486

• Swiss Prot:

  Q9H300

• Accession Number:

  NP_001032728

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Chicken, Non-Human Primate

• Immunogen:

  Synthetic peptide to the C-terminus.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Apoptosis

• Purification:

  Affinity Purified

• Concentration:

  Batch dependent

• Modification:

  None

• Shipping Conditions:

  Dry Ice

• Fragment:

  IgG

• Applications Notes:

  ELISA, Western (immuno) blotting, Immunostaining (in testing)

• Symbol:

  PARL

• NCBI Official Name:

  Presenilin associated, rhomboid-like

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Jeyaraju DV, Xu L, Letellier MC, Bandaru S, Zunino R, Berg EA, McBride HM, Pellegrini L., Phosphorylation and cleavage of presenilin-associated rhomboid-like protein (PARL) promotes changes in mitochondrial morphology., Proc Natl Acad Sci U S A. 2006 Dec 5;103 (49) :18562-7.

• Background Reference 02:

  Cipolat S, Rudka T, Hartmann D, Costa V, Serneels L, Craessaerts K, Metzger K, Frezza C, Annaert W, D'Adamio L, Derks C, Dejaegere T, Pellegrini L, D'Hooge R, Scorrano L, De Strooper B., Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling., Cell. 2006 Jul 14;126 (1) :27-9.

• Other Product Names:

  Presenilin associated, rhomboid-like protein , PSARL, PSARL1, RHBDS1, PRO2207, PSENIP2

• Tested Applications:

  ELISA, WB, IHC

• Protein ID:

  143811433

• Physical Properties:

  Liquid