PARN Antibody

• Background :

  The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly (A) as the substrate, hence, efficiently degrades poly (A) tails of mRNAs. Exonucleolytic degradation of the poly (A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID :

  5073

• Swiss Prot :

  O95453

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human PARN (NP_002573.1) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Other

• Purification :

  Affinity purification

• Positive Control :

  A-549

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 73kDa

• Fragment :

  IgG

• Symbol :

  PARN

• Positive Control 2 :

  MCF7

• Positive Control 3 :

  HepG2

• Positive Control 4 :

  HeLa

• NCBI Official Name :

  Poly (A) -specific ribonuclease

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  DAN, DKCB6, PFBMFT4, poly (A) -specific ribonuclease PARN, deadenylating nuclease, deadenylation nuclease, polyadenylate-specific ribonuclease

• Tested Applications :

  WB, IF

• Physical Properties :

  Liquid