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PAG/Cbp Antibody

CAT: 0223-36-345Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0223-36-345Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PAG [Cbp] is a ubiquitously expressed transmembrane adapter protein. Depending on its phosphorylation status, it appears as diffuse band (s) of 80-90kDa by SDS-PAGE, with phosphorylation leading to a shift towards a higher apparent molecular mass. Tyrosine phosphorylated PAG recruits Csk to the membrane and negatively regulates Src family kinases via Csk-mediated phosphorylation. Upon T cell receptor engagement, PAG becomes dephosphorylated, thereby displacing Csk from the membrane and enabling the activation of the Src kinases Fyn and Lck. PAG negatively regulates TCR (T cell antigen receptor) -mediated signaling in T cells and FCER1 (high affinity immunoglobulin epsilon receptor) -mediated signaling in mast cells. It promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. It inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins and may be involved in cell adhesion signaling.
NCBI Gene ID
64019
Swiss Prot
Q9JM80
Accession Number
81868799
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide corresponding to aa 412-424 of the N-terminal rat PAG including an additional N-terminal Cys residue.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Innate Immunity
Purification
Antigen affinity purified.
Concentration
1 mg/ml
Buffer
Liquid. In PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C.
Specificity
Recognizes mouse, rat and human PAG/Cbp.
Applications Notes
Immunocytochemistry: (1:50) . Immunoprecipitation: (5ug/sample) . Western Blot: (1:1,000) . Optimal conditions must be determined individually for each application.
Symbol
Pag1
NCBI Official Name
Phosphoprotein membrane anchor with glycosphingolipid microdomains 1
NCBI Organism
Rattus norvegicus
Other Product Names
Phosphoprotein Associated with Glycosphingolipid-enriched Microdomains 1; Csk-binding Protein
Tested Applications
ICC, IP, WB
Protein ID
Q9JM80
Physical Properties
Liquid

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