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Clusterin Antibody

CAT: 0223-36-299Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0223-36-299Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Clusterin shares homology with the small heat shock protein family of molecular chaperones. The mature secreted form of the protein is a glycosylated, 80-kDa disulfide-linked heterodimer of alpha and beta subunits (produced by internal cleavage) . Clusterin is expressed in virtually all tissues and found in all human fluids. It is involved in numerous physiological processes important for carcinogenesis and tumor growth, including apoptotic cell death, cell cycle regulation, DNA repair, cell adhesion, tissue remodeling, lipid transportation, membrane recycling, and immune system regulation. Clusterin also exists as a nuclear protein. The secreted form of Clusterin has extracellular chaperone and anti-apoptotic activities while the nuclear form acts as a proapoptotic factor.
NCBI Gene ID
1191
Swiss Prot
P10909
Accession Number
42716297
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant human clusterin (nuclear form) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Immunology, Innate Immunity, Obesity
Concentration
1 mg/ml
Buffer
Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Stable for at least 6 months after receipt when stored at -20˚ C.
Specificity
Recognizes human clusterin. Detects a band of ~49kDa by Western blot.
Applications Notes
ELISA: (direct and indirect: 1:2,000-1:5,000) . Western Blot: (1:2,000-1:5,000 using ECL; suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk; suggested incubation time is 1 hour at room temperature) . Optimal conditions must be determined individually for each application.
Symbol
CLU
NCBI Official Name
Clusterin
NCBI Organism
Homo sapiens
Other Product Names
TRPM-2; Apolipoprotein J; APO-J; CLI; CLU; SGP-2
Tested Applications
ELISA, WB
Protein ID
NP_001822
Physical Properties
Liquid

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