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Clusterin Recombinant Protein

CAT: 0223-96-191Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-96-191Size:0.1 mg
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Background
Clusterin (CLU) is also known as dimeric acidic glycoprotein (DAG protein), testosterone repressed prostate message-2 (TRPM-2), sulfated glycoprotein-2 (SGP-2) and complement lysis inhibitor (CLI), is a secreted multifunctional glycoprotein protein which belongs to the clusterin family. Intracellular cleavages of the precursor of clusterin remove the signal peptide and generate comparably sized α and β chains which are secreted as an 80 kDa N­glycosylated disulfide­linked heterodimer. DAG protein is predominantly expressed in adult testis, ovary, adrenal gland, liver, heart, and brain and in many epithelial tissues during embryonic development. Clusterin involve in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Upregulation of clusterin mRNA and protein levels detected in diverse disease states and in in vitro systems have led to suggestions that it functions in membrane lipid recycling, in apoptotic cell death, and as a stress-induced secreted chaperone protein, amongst others.
CAS Number
9000-83-3
NCBI Gene ID
1191
Swiss Prot
P10909
Accession Number
NP_001822.3
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Apoptosis, Cancer, Homeostasis, Immunology, Innate Immunity, Neuroscience, Obesity
Purity
>92% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
50.9 kDa (Disulfide - linked heterodimer)
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Clusterin
NCBI Organism
Homo sapiens
Background Reference 01
Jones SE., et al., Int. J. Biochem. Cell Biol. 34 (5) : 427–431.
Background Reference 02
Poon S., et al., 2002, J. Biol. Chem. 277:39532-39540.
Background Reference 03
Leskov K.S., et al., 2003, J. Biol. Chem. 278:11590-11600.
Background Reference 04
Santilli G., et al., 2003, J. Biol. Chem. 278:38214-38219.
Other Product Names
CLU, Clusterin, AAG4, APOJ, CLI, KUB1, SGP-2, SP-40, TRPM2
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized

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