LTbetaR Antibody [3C8]

• Background:

  The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.

• NCBI Gene ID:

  17000

• Swiss Prot:

  P50284

• Accession Number:

  1729988

• Host:

  Rat

• Reactivity:

  Mouse

• Immunogen:

  Recombinant mouse LTbetaR (cysteine-rich region/aa 31-221) .

• Clonality:

  Monoclonal

• Clone:

  3C8

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies, Functional Antibodies

• Field of Research:

  Immunology, Innate Immunity

• Purification:

  >95% (SDS-PAGE)

• Concentration:

  1 mg/ml

• Buffer:

  Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Stable for at least 1 year after receipt when stored at -20˚ C.

• Fragment:

  IgG1, kappa

• Specificity:

  Recognizes mouse LTbetaR.

• Applications Notes:

  Functional Application: Agonist inducing BAFF, chemokines and integrins in vitro and in vivo.

• Symbol:

  Ltbr

• NCBI Official Name:

  Lymphotoxin B receptor

• NCBI Organism:

  Mus musculus

• Other Product Names:

  Lymphotoxin-beta Receptor; Tumor Necrosis Factor Receptor 2 Related Protein; Tumor Necrosis Factor C Receptor; Tumor Necrosis Factor Receptor Superfamily Member 3; TNFRSF3

• Tested Applications:

  Functional Assays

• Protein ID:

  P50284

• Physical Properties:

  Liquid