CD2BP2 Antibody

• Background:

  This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined.

• NCBI Gene ID:

  10421

• Swiss Prot:

  O95400

• Accession Number:

  O95400

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CD2BP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-52 amino acids from the N-terminal region of human CD2BP2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  38 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CD2BP2

• NCBI Official Name:

  CD2 antigen cytoplasmic tail-binding protein 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Heinze, M., et al. Int. Immunol. 19 (11) :1313-1318 (2007)

• Background Reference 02:

  Nielsen, T.K., et al. J. Mol. Biol. 369 (4) :902-908 (2007)

• Background Reference 03:

  Sugiyama, N., et al. Mol. Cell Proteomics 6 (6) :1103-1109 (2007)

• Background Reference 04:

  Olsen, J.V., et al. Cell 127 (3) :635-648 (2006)

• Other Product Names:

  CD2 antigen cytoplasmic tail-binding protein 2, CD2 cytoplasmic domain-binding protein 2, CD2 tail-binding protein 2, U5 snRNP 52K protein, U5-52K, CD2BP2, KIAA1178

• Tested Applications:

  WB, IHC-P, Flow

• Physical Properties:

  Liquid