CD2BP2 Antibody

• Background :

  This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined.

• NCBI Gene ID :

  10421

• Swiss Prot :

  O95400

• Accession Number :

  O95400

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This CD2BP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-52 amino acids from the N-terminal region of human CD2BP2.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Immunology

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  38 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  CD2BP2

• NCBI Official Name :

  CD2 antigen cytoplasmic tail-binding protein 2

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Heinze, M., et al. Int. Immunol. 19 (11) :1313-1318 (2007)

• Background Reference 02 :

  Nielsen, T.K., et al. J. Mol. Biol. 369 (4) :902-908 (2007)

• Background Reference 03 :

  Sugiyama, N., et al. Mol. Cell Proteomics 6 (6) :1103-1109 (2007)

• Background Reference 04 :

  Olsen, J.V., et al. Cell 127 (3) :635-648 (2006)

• Other Product Names :

  CD2 antigen cytoplasmic tail-binding protein 2, CD2 cytoplasmic domain-binding protein 2, CD2 tail-binding protein 2, U5 snRNP 52K protein, U5-52K, CD2BP2, KIAA1178

• Tested Applications :

  WB, IHC-P, Flow

• Physical Properties :

  Liquid