CD252 Antibody [RM134L] (Biotin)

• Background:

  The RM134L monoclonal antibody specifically reacts with mouse CD252, a TNF/NGF superfamily member present on activated B lymphocytes and antigen-presenting cells. On activated B cells it enhances immunoglobulin secretion and cell proliferation. CD252 is also known as the OX-40 ligand and interacts with the OX-40 antigen found on the surface of activated T cells. The RML134L is reported to block the costimulatory activity of OX-40L.

• NCBI Gene ID:

  22164

• Swiss Prot:

  P43488

• Host:

  Rat

• Reactivity:

  Mouse

• Clonality:

  Monoclonal

• Clone:

  RM134L

• Conjugation:

  Biotin

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  The monoclonal antibody was purified utilizing affinity chromatography and unreacted biotin was removed from the product.

• Concentration:

  Batch dependent

• Buffer:

  Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

• Fragment:

  Rat IgG2b, kappa

• Specificity:

  The RM134L monoclonal antibody specifically reacts with mouse CD252, a TNF/NGF superfamily member present on activated B lymphocytes and antigen-presenting cells.

• Symbol:

  Tnfsf4

• NCBI Official Name:

  Tumor necrosis factor (ligand) superfamily, member 4

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Stber, E., Neurath, M., Calderhead, D., Perry Fell, H., Strober, W. (1995) . Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells.Immunity,2 (5), 507-521.

• Background Reference 02:

  Akiba, H., Oshima, H., Takeda, K., Atsuta, M., Nakano, H., Nakajima, A., ... Okumura, K. (1999) . CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells.The Journal of Immunology,162 (12), 7058-7066.

• Background Reference 03:

  Calderhead, D. M., Buhlmann, J. E., Van den Eertwegh, A. J., Claassen, E., Noelle, R. J., Fell, H. P. (1993) . Cloning of mouse Ox40: a T cell activation marker that may mediate TB cell interactions.The Journal of Immunology,151 (10), 5261-5271.

• Other Product Names:

  Ath1, gp34, Ath-1, Ox40l, TXGP1, CD134L, OX-40L, Txgp1l, Tnfsf4

• Tested Applications:

  Flow

• Physical Properties:

  Liquid