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KAT1 Antibody

CAT: 0223-55-429Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-429Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Histone acetylation, particularly of histone H4, has been proposed to play an important role in replication-dependent nucleosome assembly. The HAT1 protein contains D, A, and B motifs, which are present in many N-acetyltransferases, including those that acetylate substrates other than histones. The HAT1 holoenzyme consists of 2 subunits: the catalytic 46-kD HAT1 and the accessory p46. The p46 subunit stimulated the activity of HAT1 and bound to core histones. The HAT1 holoenzyme acetylated newly synthesized but not nucleosomal histone H4 at lys5 and lys12, and, to a lesser extent, histone H2A at lys5. HAT1 and p46 polypeptides are located in the nucleus of S-phase cells. HAT1 may play a role in telomeric silencing.
NCBI Gene ID
8520
Swiss Prot
O14929
Accession Number
O14929
Host
Rabbit
Reactivity
Human
Immunogen
This KAT1 (HAT1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 389-419 amino acids from the C-terminal region of human KAT1 (HAT1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
50 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
HAT1
NCBI Official Name
Histone acetyltransferase type B catalytic subunit
NCBI Organism
Homo sapiens
Background Reference 01
Gronroos, E., et al., Mol. Cell 10 (3) :483-493 (2002) .
Background Reference 02
Makowski, A.M., et al., J. Biol. Chem. 276 (47) :43499-43502 (2001) .
Background Reference 03
Cheung, P., et al., Mol. Cell 5 (6) :905-915 (2000) .
Background Reference 04
Verreault, A., et al., Curr. Biol. 8 (2) :96-108 (1998) .
Other Product Names
Histone acetyltransferase type B catalytic subunit, Histone acetyltransferase 1, HAT1, KAT1
Tested Applications
WB
Physical Properties
Liquid

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