KAT5 Antibody

• Background:

  KAT5 Antibody: KAT5 belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and non-histone proteins. KAT5 has been shown to play a role in DNA repair and apoptosis and is thought to play an important role in signal transduction and autophagy.

• NCBI Gene ID:

  10524

• Swiss Prot:

  Q92993

• Accession Number:

  NP_874369

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Autophagy

• Purification:

  KAT5 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1303 - Human Brain Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  KAT5 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  KAT5 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  Multiple isoforms of KAT5 are known to exist.

• Symbol:

  KAT5

• NCBI Official Name:

  K (lysine) acetyltransferase 5

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kamine J, Elangovan B, Subramanian T, et al. Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transactivator. Virology 1996; 216:357-66.

• Background Reference 02:

  Kimura A and Horikoshi M. Tip60 acetylates six lysines of a specific class of core histones in vitro. Genes Cells 1998; 3:789-800.

• Background Reference 03:

  Ikura T, Ogryzko VV, Grigoriev M, et al. Involvement of the TIP70 histone acetylase complex in DNA repair and apoptosis. Cell 2000; 102:463-73.

• Background Reference 04:

  Lin SY, Li TY, Liu Q, et al. GSK3-TIP60-ILK1 signaling pathway links growth factor deprivation to autophagy. Science 2012; 336:477-81.

• Other Product Names:

  KAT5 Antibody: TIP, ESA1, PLIP, TIP60, cPLA2, HTATIP, ZC2HC5, HTATIP1, Histone acetyltransferase KAT5, 60 kDa Tat-interactive protein, Tip60

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  36287069

• Physical Properties:

  Liquid