CLDN6 Antibody

• Background:

  Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.

• NCBI Gene ID:

  9074

• Swiss Prot:

  P56747

• Accession Number:

  P56747

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This CLDN6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 130-159 amino acids from the Central region of human CLDN6.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Zebrafish

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  23 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CLDN6

• NCBI Official Name:

  Claudin-6

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Wu, Q., et al. Eur. J. Cancer Prev. 19 (3) :186-194 (2010)

• Background Reference 02:

  Kleinschmidt-DeMasters, B.K., et al. Am. J. Surg. Pathol. 34 (3) :341-354 (2010)

• Background Reference 03:

  Rendon-Huerta, E., et al.Gastrointest Cancer 41 (1) :52-59 (2010)

• Background Reference 04:

  Wu, Q., et al. Zhonghua Yi Xue Za Zhi 90 (6) :407-412 (2010)

• Other Product Names:

  Claudin-6, Skullin, CLDN6

• Tested Applications:

  WB

• Protein ID:

  90183180

• Physical Properties:

  Liquid