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CLDN6 Antibody

CAT: 0223-55-362Size: 200 µLDry Ice: NoHazardous: No
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CAT#:0223-55-362Size:200 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.
NCBI Gene ID
9074
Swiss Prot
P56747
Accession Number
P56747
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This CLDN6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 130-159 amino acids from the Central region of human CLDN6.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Zebrafish
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
23 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CLDN6
NCBI Official Name
Claudin-6
NCBI Organism
Homo sapiens
Background Reference 01
Wu, Q., et al. Eur. J. Cancer Prev. 19 (3) :186-194 (2010)
Background Reference 02
Kleinschmidt-DeMasters, B.K., et al. Am. J. Surg. Pathol. 34 (3) :341-354 (2010)
Background Reference 03
Rendon-Huerta, E., et al.Gastrointest Cancer 41 (1) :52-59 (2010)
Background Reference 04
Wu, Q., et al. Zhonghua Yi Xue Za Zhi 90 (6) :407-412 (2010)
Other Product Names
Claudin-6, Skullin, CLDN6
Tested Applications
WB
Protein ID
90183180
Physical Properties
Liquid

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