CLDN7 Antibody

• Background:

  This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.

• NCBI Gene ID:

  1366

• Swiss Prot:

  O95471

• Accession Number:

  O95471

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CLDN7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172-201 amino acids from the C-terminal region of human CLDN7.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  22 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CLDN7

• NCBI Official Name:

  Claudin-7

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kojima, F., et al. Oncol. Rep. 23 (4) :927-931 (2010)

• Background Reference 02:

  Rendon-Huerta, E., et al.Gastrointest Cancer 41 (1) :52-59 (2010)

• Background Reference 03:

  Ouban, A., et al. Histol. Histopathol. 25 (1) :83-90 (2010)

• Background Reference 04:

  Kaarteenaho, R., et al. Respir. Res. 11, 59 (2010) :

• Other Product Names:

  Claudin-7, CLDN-7, CLDN7, CEPTRL2, CPETRL2

• Tested Applications:

  WB, IHC-P, Flow

• Physical Properties:

  Liquid