CLDN2 Antibody

• Background:

  This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.

• NCBI Gene ID:

  9075

• Swiss Prot:

  P57739

• Accession Number:

  P57739

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CLDN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 174-201 amino acids from the C-terminal region of human CLDN2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  25 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CLDN2

• NCBI Official Name:

  Claudin-2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Smith, A.J., et al. J. Acquir. Immune Defic. Syndr. 55 (3) :306-315 (2010)

• Background Reference 02:

  Kojima, F., et al. Oncol. Rep. 23 (4) :927-931 (2010)

• Background Reference 03:

  Szakal, D.N., et al. Virchows Arch. 456 (3) :245-250 (2010)

• Background Reference 04:

  Buchert, M., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (6) :2628-2633 (2010)

• Other Product Names:

  Claudin-2, SP82, CLDN2

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  12229749

• Physical Properties:

  Liquid