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C2 Antibody

CAT: 0223-55-321Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-321Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.
NCBI Gene ID
717
Swiss Prot
P06681
Accession Number
P06681
Host
Rabbit
Reactivity
Human, Hamster
Immunogen
This C2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-176 amino acids from the N-terminal region of human C2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
83 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
C2
NCBI Official Name
Complement C2
NCBI Organism
Homo sapiens
Background Reference 01
Hu, M., et al. Pharmacogenet. Genomics 20 (10) :634-637 (2010)
Background Reference 02
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 03
Liu, X., et al. Retina (Philadelphia, Pa.) 30 (8) :1177-1184 (2010)
Background Reference 04
Han, S., et al. Hum. Immunol. 71 (7) :727-730 (2010)
Other Product Names
Complement C2, C3/C5 convertase, Complement C2b fragment, Complement C2a fragment, C2
Tested Applications
WB
Protein ID
3915642
Physical Properties
Liquid

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