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MYSM1 Antibody

CAT: 0223-55-235Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-235Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR) -induced gene activation.
NCBI Gene ID
114803
Swiss Prot
Q5VVJ2
Accession Number
Q5VVJ2
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This MYSM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-139 amino acids from the N-terminal region of human MYSM1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
95 kDa
Fragment
Rabbit Ig
Symbol
MYSM1
NCBI Official Name
Histone H2A deubiquitinase MYSM1
NCBI Organism
Homo sapiens
Background Reference 01
Dephoure, N., et al. Proc. Natl. Acad. Sci. U.S.A. 105 (31) :10762-10767 (2008)
Background Reference 02
Zhu, P., et al. Mol. Cell 27 (4) :609-621 (2007)
Background Reference 03
Matsuoka, S., et al. Science 316 (5828) :1160-1166 (2007)
Background Reference 04
Yoneyama, M., et al. J. Mol. Biol. 369 (1) :222-238 (2007)
Other Product Names
Histone H2A deubiquitinase MYSM1, 2A-DUB, 3419-, Myb-like, SWIRM and MPN domain-containing protein 1, MYSM1, KIAA1915
Tested Applications
WB, Flow
Protein ID
74756898
Physical Properties
Liquid

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