MYSM1 Antibody

• Background :

  Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR) -induced gene activation.

• NCBI Gene ID :

  114803

• Swiss Prot :

  Q5VVJ2

• Accession Number :

  Q5VVJ2

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  This MYSM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-139 amino acids from the N-terminal region of human MYSM1.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Other

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  95 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  MYSM1

• NCBI Official Name :

  Histone H2A deubiquitinase MYSM1

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Dephoure, N., et al. Proc. Natl. Acad. Sci. U.S.A. 105 (31) :10762-10767 (2008)

• Background Reference 02 :

  Zhu, P., et al. Mol. Cell 27 (4) :609-621 (2007)

• Background Reference 03 :

  Matsuoka, S., et al. Science 316 (5828) :1160-1166 (2007)

• Background Reference 04 :

  Yoneyama, M., et al. J. Mol. Biol. 369 (1) :222-238 (2007)

• Other Product Names :

  Histone H2A deubiquitinase MYSM1, 2A-DUB, 3419-, Myb-like, SWIRM and MPN domain-containing protein 1, MYSM1, KIAA1915

• Tested Applications :

  WB, Flow

• Protein ID :

  74756898

• Physical Properties :

  Liquid