CASC4 Antibody

• Background:

  The increased expression level of this gene is associated with HER-2/neu proto-oncogene overexpression. Amplification and resulting overexpression of this proto-oncogene are found in approximately 30% of human breast and 20% of human ovarian cancers. Further characterization of the product of this gene may yield insight into the fundamental biology and pathogenetic effects of HER-2/neu overexpression in human breast and ovarian cancer cells. Alternatively spliced variants encoding different isoforms have been identified for this gene.

• NCBI Gene ID:

  113201

• Swiss Prot:

  Q6P4E1

• Accession Number:

  Q6P4E1

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This CASC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-365 amino acids from the C-terminal region of human CASC4.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  49 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CASC4

• NCBI Official Name:

  Protein CASC4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Lamesch, P., et al. Genomics 89 (3) :307-315 (2007)

• Background Reference 02:

  Clark, H.F., et al. Genome Res. 13 (10) :2265-2270 (2003)

• Background Reference 03:

  Sato, T., et al. Onkologie 26 (3) :268-271 (2003)

• Background Reference 04:

  Scheer, M., et al. Mund Kiefer Gesichtschir 7 (3) :138-145 (2003)

• Other Product Names:

  Protein CASC4, Cancer susceptibility candidate gene 4 protein, CASC4

• Tested Applications:

  WB, Flow

• Protein ID:

  74737334

• Physical Properties:

  Liquid