CASC5 Antibody

CAT: 0223-14-798Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-14-798Size:100 µL
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Background
The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t (11;15) (q23; q14) . Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4) . Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed.
NCBI Gene ID
57082
Swiss Prot
Q8NG31
Host
Rabbit
Reactivity
Human, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CASC5 (NP_733468.3) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Stem Cell
Purification
Affinity purification
Positive Control
HepG2
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 300kDa
Fragment
IgG
Symbol
CASC5
Positive Control 2
U-87MG
Positive Control 3
HeLa
Positive Control 4
Jurkat
NCBI Official Name
Kinetochore scaffold 1
NCBI Organism
Homo sapiens
Other Product Names
AF15Q14, CASC5, CT29, D4MCPH4, PPP1R55, Spc7, hKNL-1, hSpc105, kinetochore scaffold 1, ALL1-fused gene from chromosome 15q14 protein, blinkin, bub-linking kinetochore protein, cancer susceptibility candidate 5, cancer susceptibility candidate gene 5 protein, cancer/testis antigen 29, kinetochore null 1 homolog, kinetochore-null protein 1, microcephaly, primary autosomal recessive 4, protein phosphatase 1, regulatory subunit 55
Tested Applications
WB, IHC, IF
Physical Properties
Liquid

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