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ALOXE3 Antibody

CAT: 0223-55-184Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-184Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ALOXE3 is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE) . This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin.
NCBI Gene ID
59344
Swiss Prot
Q9BYJ1
Accession Number
Q9BYJ1
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This ALOXE3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 223-252 amino acids from the Central region of human ALOXE3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
81 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
ALOXE3
NCBI Official Name
Hydroperoxide isomerase ALOXE3
NCBI Organism
Homo sapiens
Background Reference 01
Han, S., et al. Hum. Immunol. 71 (7) :727-730 (2010)
Background Reference 02
Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19 (5) :1356-1361 (2010)
Background Reference 03
Vahlquist, A., et al. J. Invest. Dermatol. 130 (2) :438-443 (2010)
Background Reference 04
Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 18 (5) :1651-1658 (2009)
Other Product Names
Hydroperoxide isomerase ALOXE3, Epidermis-type lipoxygenase 3, Epidermal LOX-3, e-LOX-3, eLOX-3, Hydroperoxy icosatetraenoate dehydratase, ALOXE3
Tested Applications
WB
Protein ID
27923803
Physical Properties
Liquid

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