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SERPINI1 Antibody

CAT: 0223-55-159Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-159Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.
NCBI Gene ID
5274
Swiss Prot
Q99574
Accession Number
Q99574
Host
Rabbit
Reactivity
Human
Immunogen
This SERPINI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-45 amino acids from the N-terminal region of human SERPINI1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
46 kDa
Fragment
Rabbit Ig
Symbol
SERPINI1
NCBI Official Name
Neuroserpin
NCBI Organism
Homo sapiens
Background Reference 01
Takehara, S., et al. J. Mol. Biol. 403 (5) :751-762 (2010)
Background Reference 02
Han, S., et al. Hum. Immunol. 71 (7) :727-730 (2010)
Background Reference 03
Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19 (5) :1356-1361 (2010)
Background Reference 04
Davies, M.J., et al. J. Biol. Chem. 284 (27) :18202-18209 (2009)
Other Product Names
Neuroserpin, Peptidase inhibitor 12, PI-12, Serpin I1, SERPINI1, PI12
Tested Applications
WB, IHC-P, IF, Flow
Protein ID
3183087
Physical Properties
Liquid

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