SERPINE1 Antibody

• Background:

  This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  5054

• Swiss Prot:

  P05121

• Accession Number:

  P05121

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SERPINE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 188-216 amino acids from the Central region of human SERPINE1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Immunology, Obesity

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  45 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  SERPINE1

• NCBI Official Name:

  Plasminogen activator inhibitor 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ma, Z., et al. Biochem. Biophys. Res. Commun. 400 (4) :569-574 (2010)

• Background Reference 02:

  Ince, D.A., et al. Genet Test Mol Biomarkers 14 (5) :643-647 (2010)

• Background Reference 03:

  Bern, M.M., et al. Clin. Appl. Thromb. Hemost. 16 (5) :574-578 (2010)

• Background Reference 04:

  Markl, B., et al.Surg Oncol 102 (3) :235-241 (2010)

• Other Product Names:

  Plasminogen activator inhibitor 1, PAI, PAI-1, Endothelial plasminogen activator inhibitor, Serpin E1, SERPINE1, PAI1, PLANH1

• Tested Applications:

  WB, Flow

• Protein ID:

  129576

• Physical Properties:

  Liquid