CD271 Antibody [CDLA271]

• Background:

  CD271/NGFR pays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity) . Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver. [UniProt]

• NCBI Gene ID:

  4804

• Swiss Prot:

  P08138

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Recombinant human protein was used as the immunogen for the CD271 antibody.

• Clonality:

  Monoclonal

• Clone:

  CDLA271

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Growth Factors

• Purification:

  Protein G affinity chromatography

• Concentration:

  0.2 mg/mL

• Buffer:

  PBS with 0.1 mg/ml BSA and 0.05% sodium azide

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.

• Fragment:

  IgG1, kappa

• Specificity:

  Does not react with Mouse or Rat

• Applications Notes:

  1. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min 2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

• Symbol:

  NGFR

• NCBI Official Name:

  Nerve growth factor receptor (TNFR superfamily, member 16)

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  NGFR Antibody: CD271, p75NTR, TNFRSF16, p75 (NTR), Gp80-LNGFR, Tumor necrosis factor receptor superfamily member 16, NGF receptor

• Tested Applications:

  Flow, IF, IHC-P

• Physical Properties:

  Liquid