TOP2A Antibody [TOP2A/1362]

• Background:

  This mAb recognizes an ~170kDa protein which is identified as Topoisomerase IIa, and shows no cross-reaction with Topoisomerase IIb or I. Topo IIa plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells. Topo IIa is also implicated in drug resistance of tumor cells.

• NCBI Gene ID:

  7153

• Swiss Prot:

  P11388

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Amino acids 1352-1493 from the human protein were used as the immunogen for this TOP2A antibody.

• Clonality:

  Monoclonal

• Clone:

  TOP2A/1362

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer

• Purification:

  Protein G affinity chromatography

• Concentration:

  0.2 mg/mL

• Buffer:

  PBS with 0.1 mg/ml BSA and 0.05% sodium azide

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.

• Fragment:

  IgG2b, kappa

• Symbol:

  TOP2A

• NCBI Official Name:

  Topoisomerase (DNA) II alpha 170kDa

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  DNA topoisomerase 2-alpha, DNA topoisomerase II, alpha isozyme, TOP2A, TOP2

• Tested Applications:

  WB, Flow, IF, IHC

• Physical Properties:

  Liquid