Products for Research Use Only
RegisterLogin

TOP2A Antibody

CAT: 0223-58-309Size: 400 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-58-309Size:400 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.
NCBI Gene ID
7153
Swiss Prot
P11388
Accession Number
P11388
Host
Rabbit
Reactivity
Human
Immunogen
This TOP2A/Topo? antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1434-1461 amino acids from the C-terminal region of human TOP2A/Topo?.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
174 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
TOP2A
NCBI Official Name
DNA topoisomerase 2-alpha
NCBI Organism
Homo sapiens
Background Reference 01
Vranic, S., et al. Hum. Pathol. 41 (11) :1617-1623 (2010)
Background Reference 02
Chen, H., et al. Am. J. Surg. Pathol. 34 (9) :1250-1257 (2010)
Background Reference 03
Ye, J., et al. Cell 142 (2) :230-242 (2010)
Background Reference 04
Rossi, E., et al. Histopathology 57 (1) :81-89 (2010)
Other Product Names
DNA topoisomerase 2-alpha, DNA topoisomerase II, alpha isozyme, TOP2A, TOP2
Tested Applications
WB
Protein ID
13959709
Physical Properties
Liquid

Related Products

CatalogName
79-874TOP2A (phospho Thr1343) Antibody
64-160WAS Antibody
60-596WAS Antibody
13-349WAS Antibody
62-828Neprilysin Antibody
61-580CAPZB Antibody
55-580HCG_2024410 Antibody
30-580ACPT Antibody
19-580FABP3 Antibody
15-580POMGNT2 Antibody

Alternative Products

CatalogName
20R-1304TOP2A antibody

Popular Products