N-Cadherin Antibody [CDH2/1573]

• Background:

  Recognizes a protein of ~140kDa, identified as N-Cadherin (NCAD), also known as Cadherin 2, CDH2 and CD325. Cadherin 2 is a 140 kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. Expression of Cadherin 2 has been reported on a variety of normal tissues including neuronal, endothelial and muscle cells, and a subpopulation of early hematopoietic progenitor cells. Results aid in the classification of malignant non-carcinomatous neoplasms including mesotheliomas, chordomas, synovial sarcomas, malignant melanomas, epithelioid sarcomas, epithelioid angiosarcomas, clear cell sarcomas as well as serous and endometrioid tumors of the ovary have been demonstrated to be Cadherin 2 positive, whereas mucinous tumors are negative. Other Cadherin 2-positive neoplasms include renal cell carcinomas and some variant breast tumors, including medullary breast carcinomas and sarcomatoid metaplastic breast carcinomas.

• NCBI Gene ID:

  1000

• Swiss Prot:

  P19022

• Host:

  Mouse

• Reactivity:

  Human, Mouse

• Immunogen:

  A human partial recombinant protein corresponding to the intracellular portion of CDH2 was used as the immunogen for this Cadherin 2 antibody.

• Clonality:

  Monoclonal

• Clone:

  CDH2/1573

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction, Stem Cell

• Purification:

  Protein G affinity chromatography

• Concentration:

  0.2 mg/mL

• Buffer:

  PBS with 0.1 mg/ml BSA and 0.05% sodium azide

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.

• Fragment:

  IgG1, kappa

• Symbol:

  CDH2

• NCBI Official Name:

  Cadherin 2, type 1, N-cadherin (neuronal)

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  CDH2, CDw325, CDHN, Cadherin-2, CD325, CD325 antigen, N Cadherin, N-cadherin, NCAD, Neural cadherin, N-cadherin 1, Neural-cadherin

• Tested Applications:

  Flow, WB, IF, IHC-P

• Physical Properties:

  Liquid