BRCA1 Antibody [BRCA1/1398]

• Background:

  BRCA1 (Breast cancer type 1 susceptibility protein) is a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC) . This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.

• NCBI Gene ID:

  672

• Swiss Prot:

  P38398

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Amino acids 445-620 were used as the immunogen for the BRCA1 antibody.

• Clonality:

  Monoclonal

• Clone:

  BRCA1/1398

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle

• Purification:

  Protein G affinity chromatography

• Concentration:

  0.2 mg/mL

• Buffer:

  PBS with 0.1 mg/ml BSA and 0.05% sodium azide

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.

• Fragment:

  IgG1

• Symbol:

  BRCA1

• NCBI Official Name:

  Breast cancer 1, early onset

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Breast cancer type 1 susceptibility protein, 632-, RING finger protein 53, BRCA1, RNF53

• Tested Applications:

  Flow, IF, IHC-P

• Physical Properties:

  Liquid