CD22 Antibody [2D6]

• Background:

  CD22, also known as Lyb-8, is a heterodimeric transmembrane glycoprotein and a member of a structurally related group of immunoglobulin (Ig) superfamily domain-containing proteins called the sialoadhesin family. It is detected in the cytoplasm early in B cell development (late pro-B cell stage), appears on the cell surface concomitant with IgD, and is found on most IgM+IgD+ mature B lymphocytes. Expression is lost with terminal differentiation of B cells and is absent on plasma cells. Activation of B cells via cross-linking of surface Ig increases CD22 expression. CD22 associates with the B cell receptor (BCR) complex and mediates intercellular adhesion. Its intracellular domain is phosphorylated after antigen receptor cross-linking and is involved in negative regulation of B cell activation.

• NCBI Gene ID:

  12483

• Swiss Prot:

  P35329

• Accession Number:

  P35329

• Host:

  Rat

• Reactivity:

  Mouse

• Immunogen:

  Splenic lymphocyte plasma membranes from CBA x C57 F1 mice

• Clonality:

  Monoclonal

• Clone:

  [2D6]

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Stem Cell, Immunology

• Concentration:

  0.5 mg/mL

• Buffer:

  Supplied in PBS

• Modification:

  None

• Shipping Conditions:

  Dry Ice

• Storage Conditions:

  Store vial at -20˚ C

• Fragment:

  IgG1

• Specificity:

  CD22

• Applications Notes:

  CD22 Antibody [2D6] for use in flow cytometry, immunohistochemistry / immunocytochemistry, immunoprecipitation, and activation assays.

• Symbol:

  Cd22

• NCBI Official Name:

  CD22 antigen

• NCBI Organism:

  Mus musculus

• Other Product Names:

  Lyb-8, Leu-14, BL-CAM

• Tested Applications:

  Flow

• Physical Properties:

  Liquid