TGFa Antibody [TGFA/1119]

• Background:

  This antibody reacts with the C-terminus of TGF alpha and shows no cross-reaction with EGF and the neuropeptide synenkephalin. TGFa is a growth factor with 33% homology to EGF, binds to EGFR, activates tyrosine phosphorylation of the receptor, and stimulates cell proliferation. It plays a role in tumor initiation by inducing the reversible transformed phenotype.

• NCBI Gene ID:

  7039

• Swiss Prot:

  P01135

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Recombinant human full-length TGF protein was used as the immunogen for the TGFa antibody.

• Clonality:

  Monoclonal

• Clone:

  TGFA/1119

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies, Functional Antibodies, Antibody Pairs

• Field of Research:

  Growth Factors

• Purification:

  Protein G affinity chromatography

• Concentration:

  0.2 mg/mL

• Buffer:

  PBS with 0.1 mg/ml BSA and 0.05% sodium azide

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.

• Fragment:

  IgG1, kappa

• Applications Notes:

  1. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min. 2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

• Symbol:

  TGFA

• NCBI Official Name:

  Transforming growth factor, alpha

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  TFGAProtransforming growth factor alpha, EGF-like TGF, TGF-alpha

• Tested Applications:

  Flow, IF, IHC-P

• Physical Properties:

  Liquid