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DC-SIGN Antibody

CAT: 0223-33-022Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0223-33-022Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) also known as CD209, is part of the Lectin family of proteins. DC-SIGN is part of the innate immune response via its modulation of Toll-like Receptors. It is present on the surface of macrophages and dendritic cells and binds mannose carbohydrates, a class of PAMPS found on bacteria, fungi and viruses. PAMP stimulated DC-SIGN activates the Raf kinases Raf-1 and B-Raf. Raf-1 phosphorylates Ser276 of NF-kB p65 which serves as a binding site for histone acetyltransferases CREB-binding protein (CBP) and p300. Acetylation of NF-kB p65 leads to enhanced and prolonged anti-inflammatory cytokine IL-10 production.
NCBI Gene ID
30835
Swiss Prot
Q9NNX6
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A recombinant protein fragment from human DC-SIGN was used as the immunogen for this antibody.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Infectious Disease
Purification
Protein A purified antibody
Concentration
0.5 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at -20˚ C. Avoid freez-thaw cycles.
Fragment
IgG
Symbol
CD209
NCBI Official Name
CD209 molecule
NCBI Organism
Homo sapiens
Other Product Names
DC-SIGN Antibody: CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1, CD209 antigen, C-type lectin domain family 4 member L
Tested Applications
WB
Physical Properties
Liquid

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