CD209 / DC-SIGN Recombinant Protein

• Background:

  CD209 is also known as CLEC4L, DC-SIGN and CD209 antigen. Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.

• NCBI Gene ID:

  30835

• Swiss Prot:

  Q9NNX6

• Accession Number:

  NP_066978.1

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Immunology, Signal Transduction

• Purity:

  >90% as determined by SDS-PAGE.

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  41.3 kDa

• Applications Notes:

  This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 41.3 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

• NCBI Official Name:

  CD209molecule

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Geijtenbeek TB, et al. 2000. Nat Immunol. 1 (4) :353-7.

• Background Reference 02:

  Geijtenbeek TB, et al. 2000. Cell. 100 (5) :587-97.

• Background Reference 03:

  Engering A, et al. 2002. J Immunol. 168 (5) :2118-26.

• Other Product Names:

  DC-SIGN, CD209, DC-SIGN1, CLEC4L

• Tested Applications:

  ELISA, WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3