Dnmt3a Antibody

• Background:

  CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. Dnmt3a is a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated.

• NCBI Gene ID:

  1788

• Swiss Prot:

  Q9Y6K1

• Accession Number:

  Q9Y6K1

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This Dnmt3a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 457-486 amino acids from human Dnmt3a.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat, Chicken

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  102 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  DNMT3A

• NCBI Official Name:

  DNA (cytosine-5) -methyltransferase 3A

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Xie, S., et al., Gene 236 (1) :87-95 (1999) . Robertson, K.D., et al., Nucleic Acids Res. 27 (11) :2291-2298 (1999) .

• Other Product Names:

  DNA (cytosine-5) -methyltransferase 3A, Dnmt3a, DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA, MHsaIIIA, DNMT3A

• Tested Applications:

  WB, IHC-P

• Protein ID:

  166215081

• Physical Properties:

  Liquid