AADAT Antibody

CAT: 0223-55-064Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-55-064Size:400 µL
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Background
This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Two alternative transcripts encoding the same isoform have been identified, however, additional alternative transcripts and isoforms may exist.
NCBI Gene ID
51166
Swiss Prot
Q8N5Z0
Accession Number
Q8N5Z0
Host
Rabbit
Reactivity
Human
Immunogen
This AADAT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-224 amino acids from the Central region of human AADAT.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
47 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
AADAT
NCBI Official Name
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
NCBI Organism
Homo sapiens
Background Reference 01
Han, Q., et al. Biosci. Rep. 28 (4) :205-215 (2008)
Background Reference 02
Rossi, F., et al. J. Biol. Chem. 283 (6) :3559-3566 (2008)
Background Reference 03
Han, Q., et al. J. Biol. Chem. 283 (6) :3567-3573 (2008)
Background Reference 04
Lamesch, P., et al. Genomics 89 (3) :307-315 (2007)
Other Product Names
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, KAT/AadAT, 2-aminoadipate aminotransferase, 2-aminoadipate transaminase, Alpha-aminoadipate aminotransferase, AadAT, Kynurenine aminotransferase II, Kynurenine--oxoglutarate aminotransferase II, Kynurenine--oxoglutarate transaminase 2, Kynurenine--oxoglutarate transaminase II, AADAT, KAT2
Tested Applications
WB
Protein ID
46395904
Physical Properties
Liquid

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