BCAT1 Antibody

• Background :

  This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described.

• NCBI Gene ID :

  586

• Swiss Prot :

  P54687

• Accession Number :

  P54687

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This BCAT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-107 amino acids from the Central region of human BCAT1.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Obesity, Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  43 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  BCAT1

• NCBI Official Name :

  Branched-chain-amino-acid aminotransferase, cytosolic

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Eijgelsheim, M., et al. Hum. Mol. Genet. 19 (19) :3885-3894 (2010)

• Background Reference 02 :

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 03 :

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Background Reference 04 :

  Barber, M.J., et al. PLoS ONE (3), E9763 (2010) :

• Other Product Names :

  Branched-chain-amino-acid aminotransferase, cytosolic, BCAT (c), Protein ECA39, BCAT1, BCT1, ECA39

• Tested Applications :

  WB, IHC-P

• Protein ID :

  215274162

• Physical Properties :

  Liquid