BCAT1 Antibody

• Background:

  This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described.

• NCBI Gene ID:

  586

• Swiss Prot:

  P54687

• Accession Number:

  P54687

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This BCAT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-107 amino acids from the Central region of human BCAT1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  43 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  BCAT1

• NCBI Official Name:

  Branched-chain-amino-acid aminotransferase, cytosolic

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Eijgelsheim, M., et al. Hum. Mol. Genet. 19 (19) :3885-3894 (2010)

• Background Reference 02:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 03:

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Background Reference 04:

  Barber, M.J., et al. PLoS ONE (3), E9763 (2010) :

• Other Product Names:

  Branched-chain-amino-acid aminotransferase, cytosolic, BCAT (c), Protein ECA39, BCAT1, BCT1, ECA39

• Tested Applications:

  WB, IHC-P

• Protein ID:

  215274162

• Physical Properties:

  Liquid