BCAS1 Antibody

• Background :

  BCAS1 Antibody: BCAS1 was identified through positional cloning and was found to be overexpressed in most but not all breast cancer cells lines. Little is known about this protein; BCAS1 is cytoplasmically localized and is thought to form homodimers through coiled-coil structures. High levels of BCAS1 mRNA are seen in brain and prostate tissues, with lower amounts observed in colon, intestine and testis. Cells engineered to overexpress BCAS1 did not lose anchorage-dependent growth or increase their rate of growth, suggesting that BCAS1 is not a prototypical oncogene. The BCAS1 gene was also found to be amplified in other carcinomas such as pancreatic carcinoma, suggesting that BCAS1 may play in important role in the control of cell proliferation.

• NCBI Gene ID :

  8537

• Swiss Prot :

  O75363

• Accession Number :

  EAW75575

• Host :

  Rabbit

• Reactivity :

  Human

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Cell Cycle

• Purification :

  BCAS1 Antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1302 - Human Lung Tissue Lysate

• Concentration :

  1 mg/mL

• Homology :

  Predicted species reactivity based on immunogen sequence: Rat: (75%)

• Buffer :

  BCAS1 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  BCAS1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment :

  IgG

• Symbol :

  BCAS1

• NCBI Official Name :

  Breast carcinoma amplified sequence 1

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Collins C, Rommens JM, Kowbel D, et al. Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma. Proc. Natl. Acad. Sci. USA1998; 95:8703-8.

• Background Reference 02 :

  Beardsley DI, Kowbel D, Lataxes TA, et al. Characterization of the novel amplified in breast cancer-1 (NABC1) gene product. Exp. Cell Res.2003; 290:402-13.

• Background Reference 03 :

  Loukopoulos P, Shibata T, Katoh H, et al. Genome-wide assay-based comparative genomic hybridization analysis of pancreatic adenocarcinoma: identification of genetic indicators that predict patient outcome. Cancer Sci.2007; 98:392-400.

• Other Product Names :

  BCAS1 Antibody: AIBC1, NABC1, AIBC1, Breast carcinoma-amplified sequence 1, Amplified and overexpressed in breast cancer

• Tested Applications :

  ELISA, WB, IHC-P, IF

• Protein ID :

  119595981

• Physical Properties :

  Liquid